# Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma

> **NCT03388359** · NA · UNKNOWN · sponsor: **Lithuanian University of Health Sciences** · enrollment: 60 (estimated)

## Conditions studied

- Allergic Asthma
- Airway Remodelling
- Extracellular Matrix Alteration

## Interventions

- **PROCEDURE:** Bronchial challenge with allergen
- **OTHER:** Co-culture formation
- **OTHER:** Inhibition of Wnt and Smad signaling pathways
- **OTHER:** Extracellular matrix turnover and deposition assessment
- **BIOLOGICAL:** Dermatophagoides pteronyssinus allergen
- **DEVICE:** Dosimeter ProvoX (Ganshorn)
- **BIOLOGICAL:** Eosinophils
- **BIOLOGICAL:** Airway smooth muscle cells
- **BIOLOGICAL:** Fibroblasts

## Key facts

- **NCT ID:** NCT03388359
- **Lead sponsor:** Lithuanian University of Health Sciences
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2017-06-01
- **Primary completion:** 2020-11-10
- **Final completion:** 2020-12-08
- **Target enrollment:** 60 (ESTIMATED)
- **Last updated:** 2020-09-07

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03388359

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03388359, "Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma". Retrieved via AI Analytics 2026-06-06 from https://api.ai-analytics.org/clinical/NCT03388359. Licensed CC0.

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