# Los Tres Paso: Neoadjuvant Palbociclib Monotherapy, Concurrent Chemoradiation Therapy, Adjuvant Palbociclib Monotherapy in Patients With p16INK4a Negative, HPV-Unrelated Head and Neck Squamous Cell Carcinoma

> **NCT03389477** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **Washington University School of Medicine** · enrollment: 26 (actual)

## Conditions studied

- Head and Neck Squamous Cell Carcinoma

## Interventions

- **DRUG:** Palbociclib
- **DRUG:** Cetuximab
- **DRUG:** Cisplatin
- **RADIATION:** Intensity-Modulated Radiation Therapy
- **PROCEDURE:** Tumor biopsy
- **PROCEDURE:** Peripheral blood draw

## Key facts

- **NCT ID:** NCT03389477
- **Lead sponsor:** Washington University School of Medicine
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2018-04-27
- **Primary completion:** 2022-02-15
- **Final completion:** 2027-04-06
- **Target enrollment:** 26 (ACTUAL)
- **Last updated:** 2026-04-21

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03389477

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03389477, "Los Tres Paso: Neoadjuvant Palbociclib Monotherapy, Concurrent Chemoradiation Therapy, Adjuvant Palbociclib Monotherapy in Patients With p16INK4a Negative, HPV-Unrelated Head and Neck Squamous Cell Carcinoma". Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/clinical/NCT03389477. Licensed CC0.

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