# Phase I Study of APX005M in Pediatric Central Nervous System Tumors

> **NCT03389802** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **Pediatric Brain Tumor Consortium** · enrollment: 32 (actual)

## Conditions studied

- Glioblastoma Multiforme
- High-grade Astrocytoma Not Otherwise Specified (NOS)
- CNS Primary Tumor, Not Otherwise Specified (NOS)
- Ependymoma, Not Otherwise Specified (NOS)
- Diffuse Intrinsic Pontine Gliomas (DIPG)
- Medulloblastoma

## Interventions

- **BIOLOGICAL:** APX005M treatment for recurrent or refractory primary malignant CNS tumor patients
- **BIOLOGICAL:** APX005M treatment for newly diagnosed DIPG patients

## Key facts

- **NCT ID:** NCT03389802
- **Lead sponsor:** Pediatric Brain Tumor Consortium
- **Sponsor class:** NETWORK
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2018-03-01
- **Primary completion:** 2023-09-30
- **Final completion:** 2026-06-30
- **Target enrollment:** 32 (ACTUAL)
- **Last updated:** 2026-02-20

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03389802

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03389802, "Phase I Study of APX005M in Pediatric Central Nervous System Tumors". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT03389802. Licensed CC0.

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