# Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)

> **NCT03396575** · PHASE1 · TERMINATED · sponsor: **University of Florida** · enrollment: 11 (actual)

## Conditions studied

- Diffuse Intrinsic Pontine Glioma (DIPG)
- Brain Stem Glioma

## Interventions

- **BIOLOGICAL:** TTRNA-DC vaccines with GM-CSF
- **BIOLOGICAL:** TTRNA-xALT
- **DRUG:** Cyclophosphamide + Fludarabine Lymphodepletive Conditioning
- **DRUG:** Dose-Intensified TMZ
- **DRUG:** Td vaccine
- **BIOLOGICAL:** Autologous Hematopoietic Stem Cells (HSC)

## Key facts

- **NCT ID:** NCT03396575
- **Lead sponsor:** University of Florida
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2018-07-17
- **Primary completion:** 2025-03-20
- **Final completion:** 2025-03-20
- **Target enrollment:** 11 (ACTUAL)
- **Why stopped:** Not feasible to accrue due to competing studies
- **Last updated:** 2025-10-29

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03396575

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03396575, "Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT03396575. Licensed CC0.

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