# De-escalation of Adjuvant Radio (Chemo) Therapy for HPV-positive Head-neck Squamous Cell Carcinomas

> **NCT03396718** · NA · RECRUITING · sponsor: **Technische Universität Dresden** · enrollment: 304 (estimated)

## Conditions studied

- Head-and-neck Squamous Cell Carcinoma

## Interventions

- **RADIATION:** De-escalation radio(chemo)therapy - Level 1
- **RADIATION:** De-escalation radio(chemo)therapy - Level 2
- **RADIATION:** Standard radio(chemotherapy)

## Key facts

- **NCT ID:** NCT03396718
- **Lead sponsor:** Technische Universität Dresden
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2018-11-29
- **Primary completion:** 2029-11-30
- **Final completion:** 2032-11-30
- **Target enrollment:** 304 (ESTIMATED)
- **Last updated:** 2025-09-22

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03396718

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03396718, "De-escalation of Adjuvant Radio (Chemo) Therapy for HPV-positive Head-neck Squamous Cell Carcinomas". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT03396718. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*