# Aggressive Antipyretics for Fever Reduction in CNS Malaria

> **NCT03399318** · PHASE2 · COMPLETED · sponsor: **University of Rochester** · enrollment: 256 (actual)

## Conditions studied

- Malaria
- Seizures
- Coma
- Parasitemia
- Hyperpyrexia
- Fever

## Interventions

- **DRUG:** Acetaminophen
- **DRUG:** Ibuprofen
- **DRUG:** placebo for acetaminophen
- **DRUG:** placebo for ibuprofen

## Key facts

- **NCT ID:** NCT03399318
- **Lead sponsor:** University of Rochester
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2019-01-07
- **Primary completion:** 2022-12-02
- **Final completion:** 2022-12-02
- **Target enrollment:** 256 (ACTUAL)
- **Last updated:** 2024-03-05

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03399318

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03399318, "Aggressive Antipyretics for Fever Reduction in CNS Malaria". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT03399318. Licensed CC0.

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