Infusion of Expanded Cord Blood Cells in Addition to Single Cord Blood Transplant in Treating Patients With Acute Leukemia, Chronic Myeloid Leukemia, or Myelodysplastic Syndromes

Conditions

• Acute Biphenotypic Leukemia
• Acute Lymphoblastic Leukemia
• Chronic Myelogenous Leukemia, BCR-ABL1 Positive
• Hematopoietic and Lymphoid Cell Neoplasm
• Myelodysplastic Syndrome
• Myelodysplastic Syndrome With Excess Blasts

Interventions

• BIOLOGICAL: Dilanubicel
• DRUG: Cyclophosphamide
• DRUG: Fludarabine
• DRUG: Thiotepa
• RADIATION: Total-Body Irradiation
• PROCEDURE: Umbilical Cord Blood Transplantation
• OTHER: Laboratory Biomarker Analysis
• PROCEDURE: Biospecimen Collection
• PROCEDURE: Bone Marrow Aspirate
• PROCEDURE: Bone Marrow Biopsy
• PROCEDURE: Multigated Acquisition Scan
• PROCEDURE: Electrocardiography
• PROCEDURE: Computed Tomography

Sponsor

Fred Hutchinson Cancer Center

Collaborators

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