# Infusion of Expanded Cord Blood Cells in Addition to Single Cord Blood Transplant in Treating Patients With Acute Leukemia, Chronic Myeloid Leukemia, or Myelodysplastic Syndromes

> **NCT03399773** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **Fred Hutchinson Cancer Center** · enrollment: 31 (actual)

## Conditions studied

- Acute Biphenotypic Leukemia
- Acute Lymphoblastic Leukemia
- Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Hematopoietic and Lymphoid Cell Neoplasm
- Myelodysplastic Syndrome
- Myelodysplastic Syndrome With Excess Blasts

## Interventions

- **BIOLOGICAL:** Dilanubicel
- **DRUG:** Cyclophosphamide
- **DRUG:** Fludarabine
- **DRUG:** Thiotepa
- **RADIATION:** Total-Body Irradiation
- **PROCEDURE:** Umbilical Cord Blood Transplantation
- **OTHER:** Laboratory Biomarker Analysis
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Bone Marrow Aspirate
- **PROCEDURE:** Bone Marrow Biopsy
- **PROCEDURE:** Multigated Acquisition Scan
- **PROCEDURE:** Electrocardiography
- **PROCEDURE:** Computed Tomography

## Key facts

- **NCT ID:** NCT03399773
- **Lead sponsor:** Fred Hutchinson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2022-05-10
- **Primary completion:** 2025-06-09
- **Final completion:** 2027-04-02
- **Target enrollment:** 31 (ACTUAL)
- **Last updated:** 2025-08-26

## Collaborators

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- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03399773

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03399773, "Infusion of Expanded Cord Blood Cells in Addition to Single Cord Blood Transplant in Treating Patients With Acute Leukemia, Chronic Myeloid Leukemia, or Myelodysplastic Syndromes". Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/clinical/NCT03399773. Licensed CC0.

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