# Direct Tumor Microinjection and FDG-PET in Testing Drug Sensitivity in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma, Hodgkin Lymphoma, or Stage IV Breast Cancer

> **NCT03432741** · PHASE1 · TERMINATED · sponsor: **Mayo Clinic** · enrollment: 17 (actual)

## Conditions studied

- Breast Adenocarcinoma
- Metastatic Breast Carcinoma
- Recurrent Breast Carcinoma
- Recurrent Hodgkin Lymphoma
- Recurrent Mycosis Fungoides
- Recurrent Non-Hodgkin Lymphoma
- Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
- Refractory Breast Carcinoma
- Refractory Hodgkin Lymphoma
- Refractory Mycosis Fungoides
- Refractory Nodal Marginal Zone Lymphoma
- Refractory Non-Hodgkin Lymphoma
- Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
- Stage IV Breast Cancer AJCC v6 and v7

## Interventions

- **DRUG:** Belinostat
- **DRUG:** Carfilzomib
- **DRUG:** Copanlisib Hydrochloride
- **BIOLOGICAL:** Daratumumab
- **DRUG:** Fludeoxyglucose F-18
- **DRUG:** Gemcitabine Hydrochloride
- **OTHER:** Laboratory Biomarker Analysis
- **BIOLOGICAL:** Nivolumab
- **BIOLOGICAL:** Obinutuzumab
- **BIOLOGICAL:** Pembrolizumab
- **PROCEDURE:** Positron Emission Tomography
- **BIOLOGICAL:** Rituximab
- **DRUG:** Romidepsin
- **OTHER:** Saline
- **BIOLOGICAL:** Trastuzumab

## Key facts

- **NCT ID:** NCT03432741
- **Lead sponsor:** Mayo Clinic
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2018-03-27
- **Primary completion:** 2022-08-26
- **Final completion:** 2022-10-03
- **Target enrollment:** 17 (ACTUAL)
- **Why stopped:** funding - sponsor filing Chapter 11 bankruptcy
- **Last updated:** 2025-05-26


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03432741

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03432741, "Direct Tumor Microinjection and FDG-PET in Testing Drug Sensitivity in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma, Hodgkin Lymphoma, or Stage IV Breast Cancer". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT03432741. Licensed CC0.

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