SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors
Conditions
- Anaplastic Astrocytoma
- Anaplastic Ependymoma
- Anaplastic Ganglioglioma
- Anaplastic Meningioma
- Anaplastic Oligodendroglioma
- Pleomorphic Xanthoastrocytoma, Anaplastic
- Atypical Teratoid/Rhabdoid Tumor
- Brain Cancer
- Brain Tumor
- Central Nervous System Neoplasms
- Choroid Plexus Carcinoma
- CNS Embryonal Tumor With Rhabdoid Features
- Ganglioneuroblastoma of Central Nervous System
- CNS Tumor
- Embryonal Tumor of CNS
- Ependymoma
- Glioblastoma
- Glioma
- Glioma, Malignant
- Medulloblastoma
- Medulloblastoma; Unspecified Site
- Medulloepithelioma
- Neuroepithelial Tumor
- Neoplasms
- Neoplasms, Neuroepithelial
- Papillary Tumor of the Pineal Region (High-grade Only)
- Pediatric Brain Tumor
- Pineal Parenchymal Tumor of Intermediate Differentiation (High-grade Only)
- Pineoblastoma
- Primitive Neuroectodermal Tumor
- Recurrent Medulloblastoma
- Refractory Brain Tumor
- Neuroblastoma. CNS
- Glioblastoma, IDH-mutant
- Glioblastoma, IDH-wildtype
- Medulloblastoma, Group 3
- Medulloblastoma, Group 4
- Glioma, High Grade
- Neuroepithelial Tumor, High Grade
- Medulloblastoma, SHH-activated and TP53 Mutant
- Medulloblastoma, SHH-activated and TP53 Wildtype
- Medulloblastoma, Chromosome 9q Loss
- Medulloblastoma, Non-WNT Non-SHH, NOS
- Medulloblastoma, Non-WNT/Non-SHH
- Medulloblastoma, PTCH1 Mutation
- Medulloblastoma, WNT-activated
- Ependymoma, Recurrent
- Glioma, Recurrent High Grade
- Glioma, Recurrent Malignant
- Embryonal Tumor, NOS
- Glioma, Diffuse Midline, H3K27M-mutant
- Embryonal Tumor With Multilayered Rosettes (ETMR)
- Ependymoma, NOS, WHO Grade III
- Ependymoma, NOS, WHO Grade II
- Medulloblastoma, G3/G4
- Ependymoma, RELA Fusion Positive
Interventions
- DRUG: Gemcitabine
- DRUG: ribociclib
- DRUG: sonidegib
- DRUG: trametinib
- BIOLOGICAL: filgrastim
Sponsor
St. Jude Children's Research Hospital
Collaborators