# DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine INO-3112 and Durvalumab in Treating Patients With Recurrent or Metastatic Human Papillomavirus Associated Cancers

> **NCT03439085** · PHASE2 · TERMINATED · sponsor: **M.D. Anderson Cancer Center** · enrollment: 41 (actual)

## Conditions studied

- Human Papillomavirus-16 Positive
- Human Papillomavirus-18 Positive
- Metastatic Malignant Neoplasm
- Recurrent Anal Canal Carcinoma
- Recurrent Cervical Carcinoma
- Recurrent Malignant Neoplasm
- Recurrent Penile Carcinoma
- Recurrent Vaginal Carcinoma
- Recurrent Vulvar Carcinoma
- Refractory Malignant Neoplasm
- Stage IV Anal Cancer AJCC v8
- Stage IV Cervical Cancer AJCC v8
- Stage IV Penile Cancer AJCC v8
- Stage IV Vaginal Cancer AJCC v8
- Stage IV Vulvar Cancer AJCC v8
- Stage IVA Cervical Cancer AJCC v8
- Stage IVA Vaginal Cancer AJCC v8
- Stage IVA Vulvar Cancer AJCC v8
- Stage IVB Cervical Cancer AJCC v8
- Stage IVB Vaginal Cancer AJCC v8
- Stage IVB Vulvar Cancer AJCC v8

## Interventions

- **BIOLOGICAL:** DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine MEDI0457
- **BIOLOGICAL:** Durvalumab

## Key facts

- **NCT ID:** NCT03439085
- **Lead sponsor:** M.D. Anderson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2018-11-14
- **Primary completion:** 2022-09-20
- **Final completion:** 2022-09-20
- **Target enrollment:** 41 (ACTUAL)
- **Why stopped:** Project delays
- **Last updated:** 2024-07-09

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03439085

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03439085, "DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine INO-3112 and Durvalumab in Treating Patients With Recurrent or Metastatic Human Papillomavirus Associated Cancers". Retrieved via AI Analytics 2026-05-31 from https://api.ai-analytics.org/clinical/NCT03439085. Licensed CC0.

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