# Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure

> **NCT03440970** · EARLY_PHASE1 · COMPLETED · sponsor: **Yale University** · enrollment: 20 (actual)

## Conditions studied

- Decompensated Heart Failure

## Interventions

- **DRUG:** Lysine Chloride
- **OTHER:** Placebo

## Key facts

- **NCT ID:** NCT03440970
- **Lead sponsor:** Yale University
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2019-01-15
- **Primary completion:** 2025-08-30
- **Final completion:** 2025-08-30
- **Target enrollment:** 20 (ACTUAL)
- **Last updated:** 2025-09-15

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03440970

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03440970, "Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT03440970. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*