# LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas

> **NCT03449108** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **M.D. Anderson Cancer Center** · enrollment: 30 (actual)

## Conditions studied

- Bone Sarcoma
- Dedifferentiated Chondrosarcoma
- Giant Cell Tumor of Bone
- Malignancy in Giant Cell Tumor of Bone
- Malignant Solid Neoplasm
- Ovarian Carcinosarcoma
- Platinum-Resistant Ovarian Carcinoma
- Poorly Differentiated Thyroid Gland Carcinoma
- Recurrent Osteosarcoma
- Recurrent Ovarian Carcinoma
- Refractory Osteosarcoma
- Soft Tissue Sarcoma
- Thyroid Gland Anaplastic Carcinoma
- Thyroid Gland Squamous Cell Carcinoma
- Undifferentiated High Grade Pleomorphic Sarcoma of Bone
- Triple Negative Breast Cancer

## Interventions

- **BIOLOGICAL:** Aldesleukin
- **BIOLOGICAL:** Autologous Tumor Infiltrating Lymphocytes LN-145
- **BIOLOGICAL:** Autologous Tumor Infiltrating Lymphocytes LN-145-S1
- **DRUG:** Cyclophosphamide
- **DRUG:** Fludarabine
- **BIOLOGICAL:** Ipilimumab
- **BIOLOGICAL:** Nivolumab
- **OTHER:** Quality-of-Life Assessment
- **OTHER:** Questionnaire Administration

## Key facts

- **NCT ID:** NCT03449108
- **Lead sponsor:** M.D. Anderson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2018-04-27
- **Primary completion:** 2027-04-30
- **Final completion:** 2027-04-30
- **Target enrollment:** 30 (ACTUAL)
- **Last updated:** 2025-11-21

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03449108

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03449108, "LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas". Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/clinical/NCT03449108. Licensed CC0.

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