# Prevention of Acute Exacerbation in Subjects With COPD by Bacterial Decolonization in Lower Respiratory Tract

> **NCT03449459** · EARLY_PHASE1 · COMPLETED · sponsor: **Shanghai Zhongshan Hospital** · enrollment: 144 (actual)

## Conditions studied

- Chronic Obstructive Pulmonary Disease (COPD)

## Interventions

- **DIETARY_SUPPLEMENT:** oral probiotics
- **DRUG:** aerosol inhaled amikacin
- **BIOLOGICAL:** combined vaccination

## Key facts

- **NCT ID:** NCT03449459
- **Lead sponsor:** Shanghai Zhongshan Hospital
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2018-12-01
- **Primary completion:** 2020-12-01
- **Final completion:** 2020-12-01
- **Target enrollment:** 144 (ACTUAL)
- **Last updated:** 2022-06-23

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03449459

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03449459, "Prevention of Acute Exacerbation in Subjects With COPD by Bacterial Decolonization in Lower Respiratory Tract". Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/clinical/NCT03449459. Licensed CC0.

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