# Treatment Protocol for Non-Metastatic Unilateral Retinoblastoma

> **NCT03475121** · PHASE3 · COMPLETED · sponsor: **Hospital JP Garrahan** · enrollment: 84 (actual)

## Conditions studied

- Unilateral Retinoblastoma

## Interventions

- **COMBINATION_PRODUCT:** Combination Chemotherapy plus Intrathecal Topotecan
- **COMBINATION_PRODUCT:** Higher Dose Combination Chemotherapy plus Intrathecal Topotecan
- **COMBINATION_PRODUCT:** Higher Dose Combination Chemotherapy plus Intrathecal Topotecan and Orbital Radiotherapy
- **OTHER:** No Adjuvant Therapy

## Key facts

- **NCT ID:** NCT03475121
- **Lead sponsor:** Hospital JP Garrahan
- **Sponsor class:** OTHER_GOV
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2018-01-01
- **Primary completion:** 2023-01-31
- **Final completion:** 2025-03-28
- **Target enrollment:** 84 (ACTUAL)
- **Last updated:** 2025-04-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03475121

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03475121, "Treatment Protocol for Non-Metastatic Unilateral Retinoblastoma". Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/clinical/NCT03475121. Licensed CC0.

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