# Preoperative Vitamin B12 and Folic Acid on POCD in Elderly Non-cardiac Surgical Patients

> **NCT03485404** · NA · TERMINATED · sponsor: **Xijing Hospital** · enrollment: 40 (actual)

## Conditions studied

- Post Operative Cognitive Dysfunction

## Interventions

- **DRUG:** methylcobalamin
- **DRUG:** Folic Acid
- **OTHER:** Placebo for methylcobalamin
- **OTHER:** Placebo for folic acid
- **PROCEDURE:** non-cardiac surgery
- **BEHAVIORAL:** NPB test

## Key facts

- **NCT ID:** NCT03485404
- **Lead sponsor:** Xijing Hospital
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2019-01-10
- **Primary completion:** 2021-07-29
- **Final completion:** 2021-07-29
- **Target enrollment:** 40 (ACTUAL)
- **Why stopped:** Due to slow recruiment. Only 40 patients were recruited in four years.
- **Last updated:** 2021-08-04

## Collaborators

- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03485404

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03485404, "Preoperative Vitamin B12 and Folic Acid on POCD in Elderly Non-cardiac Surgical Patients". Retrieved via AI Analytics 2026-05-30 from https://api.ai-analytics.org/clinical/NCT03485404. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*