Phase I/II Study of Immunotherapy Combination BN-Brachyury Vaccine, M7824, N-803 and Epacadostat (QuEST1)

NCT03493945 · clinicaltrials.gov ↗

PHASE1,PHASE2

Phase

COMPLETED

Status

59

Enrollment

NIH

Sponsor class

Conditions

Metastatic Castration-resistant Prostate Cancer
Prostate Cancer
Prostate Neoplasm
Advanced Solid Tumor
Solid Tumor
Non-metastatic Castration-resistant Prostate Cancer

Interventions

BIOLOGICAL: M7824
DRUG: N-803
BIOLOGICAL: MVA-BN-Brachyury
BIOLOGICAL: FPV-Brachyury
DRUG: Epacadostat
DRUG: Acetaminophen
DRUG: Ibuprofen
DRUG: Naproxen
OTHER: Benadryl
DIAGNOSTIC_TEST: EKG
DIAGNOSTIC_TEST: Bone scan
DIAGNOSTIC_TEST: CT chest, abdomen and pelvis
DIAGNOSTIC_TEST: MRI

Sponsor

National Cancer Institute (NCI)