# DIRECT-SAFE: A Randomized Controlled Trial of DIRECT Endovascular Clot Retrieval Versus Standard Bridging Thrombolysis With Endovascular Clot Retrieval

> **NCT03494920** · PHASE3 · COMPLETED · sponsor: **Neuroscience Trials Australia** · enrollment: 295 (actual)

## Conditions studied

- Ischemic Stroke

## Interventions

- **OTHER:** Direct endovascular clot retrieval
- **OTHER:** Bridging thrombolysis followed by ECR

## Key facts

- **NCT ID:** NCT03494920
- **Lead sponsor:** Neuroscience Trials Australia
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2018-04-27
- **Primary completion:** 2021-09-08
- **Final completion:** 2021-09-08
- **Target enrollment:** 295 (ACTUAL)
- **Last updated:** 2022-06-16

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03494920

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03494920, "DIRECT-SAFE: A Randomized Controlled Trial of DIRECT Endovascular Clot Retrieval Versus Standard Bridging Thrombolysis With Endovascular Clot Retrieval". Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/clinical/NCT03494920. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*