# Pediatric Hodgkin Lymphoma Treatment Trial With Low Cumulative Doses of Chemotherapy Agents and Reduced Radiation.

> **NCT03500133** · PHASE4 · RECRUITING · sponsor: **Hospital JP Garrahan** · enrollment: 500 (estimated)

## Conditions studied

- Pediatric Hodgkin's Disease

## Interventions

- **RADIATION:** No radiotherapy if CR at the end of chemotherapy.
- **DRUG:** Low risk with complete early response after two cycles of ABVD chemotherapy schedule. Only one more ABVD course is delivered.
- **DRUG:** Low risk with partial remisssion after 4 cycles of ABVD chemotherapy schedule. Two ESHAP courses are delivered.
- **RADIATION:** IN 30Gy RT in case of PR at the end of chemotherapy
- **DRUG:** Intermediate risk with complete early response after two cycles of ABVD chemotherapy schedule. Three more ABVD courses are delivered.
- **DRUG:** Intermediate risk with partial remission after two cycles of ABVD chemotherapy schedule. Four more chemotherapy courses are delivered alternating ESHAP and ABVD.
- **DRUG:** High risk with complete early response after 1 ABVD and 1 ESHAP courses. Four more chemotherapy courses are delivered alternating ESHAP and ABVD.
- **DRUG:** High risk with partial remission after 1 ABVD and 1 ESHAP courses. Six more chemotherapy courses are delivered alternating ESHAP and ABVD.
- **DRUG:** Low risk with partial remission at early response assessment after two cycles of ABVD chemotherpay schedule. Two ABVD courses are delivered.

## Key facts

- **NCT ID:** NCT03500133
- **Lead sponsor:** Hospital JP Garrahan
- **Sponsor class:** OTHER_GOV
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2017-10-06
- **Primary completion:** 2027-10-31
- **Final completion:** 2032-10-31
- **Target enrollment:** 500 (ESTIMATED)
- **Last updated:** 2025-04-16


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03500133

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03500133, "Pediatric Hodgkin Lymphoma Treatment Trial With Low Cumulative Doses of Chemotherapy Agents and Reduced Radiation.". Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/clinical/NCT03500133. Licensed CC0.

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