# PeriOperative ISchemic Evaluation-3 Trial

> **NCT03505723** · PHASE3 · COMPLETED · sponsor: **Population Health Research Institute** · enrollment: 9535 (actual)

## Conditions studied

- Perioperative Bleeding
- Venous Thrombosis
- Arterial Thrombosis

## Interventions

- **DRUG:** Tranexamic Acid
- **DRUG:** Placebo (Saline)
- **OTHER:** Perioperative hypotension-avoidance strategy
- **OTHER:** Perioperative hypertension-avoidance strategy

## Key facts

- **NCT ID:** NCT03505723
- **Lead sponsor:** Population Health Research Institute
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2018-06-27
- **Primary completion:** 2021-11-08
- **Final completion:** 2023-02-03
- **Target enrollment:** 9535 (ACTUAL)
- **Last updated:** 2025-02-12


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03505723

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03505723, "PeriOperative ISchemic Evaluation-3 Trial". Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/clinical/NCT03505723. Licensed CC0.

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