# Comparison of the Balloon-Expandable Edwards Valve and Self-Expandable CoreValve Evolut R or Evolut PRO System for the Treatment of Small, Severely Dysfunctional Surgical Aortic Bioprotheses. The 'LYTEN' Trial

> **NCT03520101** · NA · ACTIVE_NOT_RECRUITING · sponsor: **Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec** · enrollment: 102 (actual)

## Conditions studied

- Aortic Valve Stenosis
- Regurgitation, Aortic
- Prosthesis Failure

## Interventions

- **PROCEDURE:** TAVI_ViV procedure with Edwards valve
- **PROCEDURE:** TAVI_ViV procedure with CoreValve system

## Key facts

- **NCT ID:** NCT03520101
- **Lead sponsor:** Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2017-05-10
- **Primary completion:** 2022-02-22
- **Final completion:** 2030-05-31
- **Target enrollment:** 102 (ACTUAL)
- **Last updated:** 2026-03-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03520101

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03520101, "Comparison of the Balloon-Expandable Edwards Valve and Self-Expandable CoreValve Evolut R or Evolut PRO System for the Treatment of Small, Severely Dysfunctional Surgical Aortic Bioprotheses. The 'LYTEN' Trial". Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/clinical/NCT03520101. Licensed CC0.

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