# Comparing ATG or Post-Transplant Cyclophosphamide to Calcineurin Inhibitor-Methotrexate as GVHD Prophylaxis After Myeloablative Unrelated Donor Peripheral Blood Stem Cell Transplantation

> **NCT03602898** · PHASE2 · WITHDRAWN · sponsor: **Fred Hutchinson Cancer Center**

## Conditions studied

- Acute Lymphoblastic Leukemia in Remission
- Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
- Chronic Myelomonocytic Leukemia
- Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Hematopoietic and Lymphoid System Neoplasm
- Myelodysplastic Syndrome
- Myelofibrosis
- Myeloproliferative Neoplasm
- Recurrent Acute Myeloid Leukemia
- Recurrent Hodgkin Lymphoma
- Recurrent Non-Hodgkin Lymphoma
- Refractory Acute Myeloid Leukemia
- Therapy-Related Acute Myeloid Leukemia

## Interventions

- **BIOLOGICAL:** Anti-Thymocyte Globulin
- **DRUG:** Busulfan
- **DRUG:** Cyclophosphamide
- **DRUG:** Cyclosporine
- **DRUG:** Fludarabine Phosphate
- **DRUG:** Methotrexate
- **PROCEDURE:** Peripheral Blood Stem Cell Transplantation
- **OTHER:** Quality-of-Life Assessment
- **OTHER:** Questionnaire Administration
- **DRUG:** Tacrolimus
- **RADIATION:** Total-Body Irradiation

## Key facts

- **NCT ID:** NCT03602898
- **Lead sponsor:** Fred Hutchinson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** WITHDRAWN
- **Start date:** 2021-06-01
- **Primary completion:** 2023-09-17
- **Final completion:** 2023-09-17
- **Target enrollment:** 0 (ACTUAL)
- **Why stopped:** Insufficient funding
- **Last updated:** 2021-06-30


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03602898

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03602898, "Comparing ATG or Post-Transplant Cyclophosphamide to Calcineurin Inhibitor-Methotrexate as GVHD Prophylaxis After Myeloablative Unrelated Donor Peripheral Blood Stem Cell Transplantation". Retrieved via AI Analytics 2026-05-30 from https://api.ai-analytics.org/clinical/NCT03602898. Licensed CC0.

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