# An Observational,Prospective Natural History Study of Early-Onset Extreme Obesity Due to Bi-Allelic Loss-of-Function Mutations in the POMC, PCSK1 or LEPR Genes

> **NCT03621007** · — · COMPLETED · sponsor: **Rhythm Pharmaceuticals, Inc.** · enrollment: 8 (actual)

## Conditions studied

- POMC Deficiency Obesity
- PCSK1 Deficiency Obesity
- LEPR Deficiency Obesity

## Interventions

_None listed._

## Key facts

- **NCT ID:** NCT03621007
- **Lead sponsor:** Rhythm Pharmaceuticals, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** COMPLETED
- **Start date:** 2019-08-06
- **Primary completion:** 2021-01-22
- **Final completion:** 2021-01-22
- **Target enrollment:** 8 (ACTUAL)
- **Last updated:** 2021-06-30


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03621007

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03621007, "An Observational,Prospective Natural History Study of Early-Onset Extreme Obesity Due to Bi-Allelic Loss-of-Function Mutations in the POMC, PCSK1 or LEPR Genes". Retrieved via AI Analytics 2026-08-12 from https://api.ai-analytics.org/clinical/NCT03621007. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*