# Surgery Followed by Risk-Directed Post-Operative Adjuvant Therapy for HPV-Related Oropharynx Squamous Cell Carcinoma: "The Minimalist Trial (MINT)"

> **NCT03621696** · PHASE2 · COMPLETED · sponsor: **Washington University School of Medicine** · enrollment: 63 (actual)

## Conditions studied

- HPV Related Oropharyngeal Squamous Cell Carcinoma

## Interventions

- **DRUG:** Cisplatin
- **RADIATION:** Intensity modulated radiation therapy
- **RADIATION:** Intensity modulated proton therapy
- **PROCEDURE:** Surgery
- **OTHER:** FACT-H&N
- **OTHER:** MD Anderson Dysphagia Inventory
- **OTHER:** University of Michigan Xerostomia Index
- **OTHER:** Scale of Subjective Total Taste Acuity
- **OTHER:** Neck Dissection Impairment Index

## Key facts

- **NCT ID:** NCT03621696
- **Lead sponsor:** Washington University School of Medicine
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2018-10-23
- **Primary completion:** 2021-03-10
- **Final completion:** 2026-03-17
- **Target enrollment:** 63 (ACTUAL)
- **Last updated:** 2026-04-21


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03621696

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03621696, "Surgery Followed by Risk-Directed Post-Operative Adjuvant Therapy for HPV-Related Oropharynx Squamous Cell Carcinoma: "The Minimalist Trial (MINT)"". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT03621696. Licensed CC0.

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