Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation

NCT03663933 · clinicaltrials.gov ↗

PHASE2

Phase

ACTIVE_NOT_RECRUITING

Status

71

Enrollment

NIH

Sponsor class

Conditions

Lymphoproliferative Disorders
Autoimmune Lymphoproliferative
Primary T-cell Immunodeficiency Disorders
Immune System Diseases
Common Variable Immunodeficiency

Interventions

DRUG: e-ATG
PROCEDURE: Immunosuppression Only Conditioning
PROCEDURE: Reduced Intensity Conditioning
DRUG: GVHD Prophylaxis
PROCEDURE: Allogeneic HSC
DRUG: Bisulfan
DRUG: Prednisone
DRUG: Cyclophosphamide
DRUG: MMF
DRUG: Mesna
DRUG: Tacrolimus
DRUG: Pentostatin
DIAGNOSTIC_TEST: PFTs
DIAGNOSTIC_TEST: DEXA
PROCEDURE: Bone Marrow Aspirate & Biopsy
DIAGNOSTIC_TEST: EKG
DIAGNOSTIC_TEST: 2D ECHO

Sponsor

National Cancer Institute (NCI)