# 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

> **NCT03670966** · PHASE1,PHASE2 · RECRUITING · sponsor: **Fred Hutchinson Cancer Center** · enrollment: 30 (estimated)

## Conditions studied

- Acute Lymphoblastic Leukemia in Remission
- Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
- Acute Myeloid Leukemia in Remission
- Chronic Myelomonocytic Leukemia
- Myelodysplastic Syndrome With Excess Blasts
- Recurrent Acute Lymphoblastic Leukemia
- Recurrent Acute Myeloid Leukemia
- Refractory Acute Lymphoblastic Leukemia
- Refractory Acute Myeloid Leukemia
- Recurrent Mixed Phenotype Acute Leukemia
- Refractory Mixed Phenotype Acute Leukemia
- Hematopoietic and Lymphoid Cell Neoplasm

## Interventions

- **BIOLOGICAL:** Astatine At 211 Anti-CD45 Monoclonal Antibody BC8-B10
- **DRUG:** Cyclophosphamide
- **RADIATION:** Total-Body Irradiation
- **PROCEDURE:** Peripheral Blood Stem Cell Transplantation
- **PROCEDURE:** Bone Marrow Transplantation
- **DRUG:** Mycophenolate Mofetil
- **BIOLOGICAL:** Recombinant Granulocyte Colony-Stimulating Factor
- **DRUG:** Fludarabine Phosphate
- **DRUG:** Tacrolimus
- **PROCEDURE:** Bone Marrow Aspiration and Biopsy
- **PROCEDURE:** Biospecimen Collection

## Key facts

- **NCT ID:** NCT03670966
- **Lead sponsor:** Fred Hutchinson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2019-07-10
- **Primary completion:** 2028-01-28
- **Final completion:** 2029-10-20
- **Target enrollment:** 30 (ESTIMATED)
- **Last updated:** 2026-05-04

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03670966

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03670966, "211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT03670966. Licensed CC0.

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