# Estrogen Receptor Beta and Mood

> **NCT03689543** · PHASE2 · COMPLETED · sponsor: **National Institute of Mental Health (NIMH)** · enrollment: 74 (actual)

## Conditions studied

- Perimenopause-Related Depression

## Interventions

- **DRUG:** Estradiol
- **DRUG:** ER Beta Agonist
- **OTHER:** Placebo
- **DRUG:** Provera

## Key facts

- **NCT ID:** NCT03689543
- **Lead sponsor:** National Institute of Mental Health (NIMH)
- **Sponsor class:** NIH
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2019-05-23
- **Primary completion:** 2024-09-09
- **Final completion:** 2024-09-09
- **Target enrollment:** 74 (ACTUAL)
- **Last updated:** 2025-09-16


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03689543

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03689543, "Estrogen Receptor Beta and Mood". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT03689543. Licensed CC0.

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