# Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus

> **NCT03701074** · PHASE2 · TERMINATED · sponsor: **University of South Alabama** · enrollment: 1 (actual)

## Conditions studied

- Patent Ductus Arteriosus
- Preterm Infant
- Bronchopulmonary Dysplasia

## Interventions

- **DRUG:** Ibuprofen and acetaminophen
- **DRUG:** Ibuprofen and placebo

## Key facts

- **NCT ID:** NCT03701074
- **Lead sponsor:** University of South Alabama
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2018-12-15
- **Primary completion:** 2020-10-30
- **Final completion:** 2020-12-02
- **Target enrollment:** 1 (ACTUAL)
- **Why stopped:** very slow enrollment. Only one patient enrolled. Termination by PI
- **Last updated:** 2026-04-30


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03701074

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03701074, "Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT03701074. Licensed CC0.

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