# Alpha-Defensin and Synovial Proteins to Improve Detection of Pediatric Septic Arthritis

> **NCT03704766** · NA · RECRUITING · sponsor: **Hospital for Special Surgery, New York** · enrollment: 442 (estimated)

## Conditions studied

- Joint Infection
- Infection of Hip Joint (Disorder)
- Infection of Shoulder Joint
- Septic Arthritis

## Interventions

- **DIAGNOSTIC_TEST:** Synovial Alpha-defensin assay
- **DIAGNOSTIC_TEST:** Synovial Neutrophil elastase assay
- **DIAGNOSTIC_TEST:** Synovial lactate assay
- **DIAGNOSTIC_TEST:** Synovial C-reactive Protein (CRP)
- **DIAGNOSTIC_TEST:** Synovial Staphylococcus spp antigen panel
- **DIAGNOSTIC_TEST:** Synovial Candida spp antigen panel
- **DIAGNOSTIC_TEST:** Synovial Enterococcus faecalis assay
- **DIAGNOSTIC_TEST:** Synovial bacterial culture by BacT/Alert
- **DIAGNOSTIC_TEST:** Synovial Cell count + differential (CBC)
- **DIAGNOSTIC_TEST:** Synovial Gram Stain
- **DIAGNOSTIC_TEST:** Synovial Leukocyte Esterase Test Strips
- **DIAGNOSTIC_TEST:** Synovial PCR for Kingella kingae
- **DIAGNOSTIC_TEST:** Serum Cell count + differential (CBC)
- **DIAGNOSTIC_TEST:** Serum erythrocyte sedimentation rate (ESR)
- **DIAGNOSTIC_TEST:** Serum C-reactive Protein (CRP)
- **DIAGNOSTIC_TEST:** Serum D-dimer
- **DIAGNOSTIC_TEST:** Serum Procalcitonin
- **DIAGNOSTIC_TEST:** Blood Cultures
- **DIAGNOSTIC_TEST:** Optional blood testing per standard of care (ASO, anti-strep, ANA, anti-DS-DNA, HLA-B27, RF, Lyme and other inflammatory/ rheumatologic markers )

## Key facts

- **NCT ID:** NCT03704766
- **Lead sponsor:** Hospital for Special Surgery, New York
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2016-06-28
- **Primary completion:** 2026-05
- **Final completion:** 2026-05
- **Target enrollment:** 442 (ESTIMATED)
- **Last updated:** 2025-06-22

## Collaborators

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- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03704766

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03704766, "Alpha-Defensin and Synovial Proteins to Improve Detection of Pediatric Septic Arthritis". Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/clinical/NCT03704766. Licensed CC0.

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