# Safety and Bone Health Study of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis

> **NCT03727022** · PHASE2 · COMPLETED · sponsor: **Biosplice Therapeutics, Inc.** · enrollment: 101 (actual)

## Conditions studied

- Knee Osteoarthritis

## Interventions

- **DRUG:** Placebo
- **DRUG:** SM04690

## Key facts

- **NCT ID:** NCT03727022
- **Lead sponsor:** Biosplice Therapeutics, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2018-11-28
- **Primary completion:** 2020-09-18
- **Final completion:** 2021-08-18
- **Target enrollment:** 101 (ACTUAL)
- **Last updated:** 2026-01-12


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03727022

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03727022, "Safety and Bone Health Study of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT03727022. Licensed CC0.

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