Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients

NCT03745326 · clinicaltrials.gov ↗

PHASE1,PHASE2

Phase

COMPLETED

Status

5

Enrollment

NIH

Sponsor class

Conditions

Gastrointestinal Cancer
Pancreatic Cancer
Gastric Cancer
Colon Cancer
Rectal Cancer

Interventions

DRUG: Cyclophosphamide
DRUG: Fludarabine
DRUG: Aldesleukin
BIOLOGICAL: anti-KRAS G12D mTCR PBL

Sponsor

National Cancer Institute (NCI)