# Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder

> **NCT03748446** · EARLY_PHASE1 · RECRUITING · sponsor: **Massachusetts General Hospital** · enrollment: 20 (estimated)

## Conditions studied

- Major Depressive Disorder
- Bipolar Depression

## Interventions

- **DRUG:** Xenon
- **DRUG:** Nitrogen gas

## Key facts

- **NCT ID:** NCT03748446
- **Lead sponsor:** Massachusetts General Hospital
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2019-12-05
- **Primary completion:** 2026-09-01
- **Final completion:** 2026-12-01
- **Target enrollment:** 20 (ESTIMATED)
- **Last updated:** 2025-05-18


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03748446

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03748446, "Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder". Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/clinical/NCT03748446. Licensed CC0.

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