# Nivolumab With DA-REPOCH Chemotherapy Regimen in Treating Patients With Aggressive B-Cell Non-Hodgkin's Lymphoma

> **NCT03749018** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **David Bond, MD** · enrollment: 30 (estimated)

## Conditions studied

- Aggressive Non-Hodgkin Lymphoma
- Ann Arbor Stage I Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma
- Ann Arbor Stage II B-Cell Non-Hodgkin Lymphoma
- Ann Arbor Stage II Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma
- Ann Arbor Stage III B-Cell Non-Hodgkin Lymphoma
- Ann Arbor Stage III Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma
- Ann Arbor Stage IV B-Cell Non-Hodgkin Lymphoma
- Ann Arbor Stage IV Primary Mediastinal (Thymic) Large B-Cell Cell Lymphoma
- Diffuse Large B-Cell Lymphoma
- High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements
- High Grade B-Cell Lymphoma, Not Otherwise Specified
- Indolent Non-Hodgkin Lymphoma
- Mediastinal B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma
- Transformed Non-Hodgkin Lymphoma

## Interventions

- **DRUG:** Cyclophosphamide
- **DRUG:** Doxorubicin Hydrochloride
- **DRUG:** Etoposide
- **BIOLOGICAL:** Nivolumab
- **DRUG:** Prednisone
- **BIOLOGICAL:** Rituximab
- **DRUG:** Vincristine Sulfate

## Key facts

- **NCT ID:** NCT03749018
- **Lead sponsor:** David Bond, MD
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2019-01-02
- **Primary completion:** 2026-02-02
- **Final completion:** 2026-12-31
- **Target enrollment:** 30 (ESTIMATED)
- **Last updated:** 2026-02-06

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03749018

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03749018, "Nivolumab With DA-REPOCH Chemotherapy Regimen in Treating Patients With Aggressive B-Cell Non-Hodgkin's Lymphoma". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT03749018. Licensed CC0.

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