# Brain Oxygen Optimization in Severe TBI, Phase 3

> **NCT03754114** · NA · ACTIVE_NOT_RECRUITING · sponsor: **University of Michigan** · enrollment: 1094 (estimated)

## Conditions studied

- Brain Injuries, Traumatic

## Interventions

- **OTHER:** ICP + PbtO2 guided management strategy
- **OTHER:** ICP guided management strategy

## Key facts

- **NCT ID:** NCT03754114
- **Lead sponsor:** University of Michigan
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2019-08-28
- **Primary completion:** 2027-11-01
- **Final completion:** 2027-11-01
- **Target enrollment:** 1094 (ESTIMATED)
- **Last updated:** 2026-05-05

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03754114

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03754114, "Brain Oxygen Optimization in Severe TBI, Phase 3". Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/clinical/NCT03754114. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*