# Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma

> **NCT03799445** · PHASE2 · TERMINATED · sponsor: **M.D. Anderson Cancer Center** · enrollment: 37 (actual)

## Conditions studied

- Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
- Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
- Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma
- Oropharyngeal Basaloid Carcinoma
- Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
- Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
- Posterior Tongue Squamous Cell Carcinoma
- Soft Palate Squamous Cell Carcinoma
- Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7
- Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7
- Tonsillar Squamous Cell Carcinoma

## Interventions

- **RADIATION:** Intensity-Modulated Radiation Therapy
- **BIOLOGICAL:** Ipilimumab
- **BIOLOGICAL:** Nivolumab
- **OTHER:** Quality-of-Life Assessment
- **OTHER:** Questionnaire Administration

## Key facts

- **NCT ID:** NCT03799445
- **Lead sponsor:** M.D. Anderson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2019-07-25
- **Primary completion:** 2025-07-25
- **Final completion:** 2026-04-14
- **Target enrollment:** 37 (ACTUAL)
- **Why stopped:** \<75% participation
- **Last updated:** 2026-04-30

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03799445

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03799445, "Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma". Retrieved via AI Analytics 2026-06-13 from https://api.ai-analytics.org/clinical/NCT03799445. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*