# Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous Cell Carcinoma

> **NCT03803774** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 13 (actual)

## Conditions studied

- Locally Recurrent Head and Neck Squamous Cell Carcinoma
- Nasopharyngeal Squamous Cell Carcinoma
- Sinonasal Squamous Cell Carcinoma

## Interventions

- **PROCEDURE:** Biopsy Procedure
- **DRUG:** Birinapant
- **PROCEDURE:** Computed Tomography
- **RADIATION:** Intensity-Modulated Radiation Therapy
- **PROCEDURE:** Magnetic Resonance Imaging
- **PROCEDURE:** Positron Emission Tomography

## Key facts

- **NCT ID:** NCT03803774
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2019-09-25
- **Primary completion:** 2023-11-15
- **Final completion:** 2026-07-09
- **Target enrollment:** 13 (ACTUAL)
- **Last updated:** 2026-04-29


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03803774

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03803774, "Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous Cell Carcinoma". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT03803774. Licensed CC0.

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