# An Exploratory Study in Healthy Volunteers to Investigate the Cross-talk Between Local Drug Concentrations in the Skin and Systemic Concentrations During Topical Bioequivalence Studies Using Dermal Sampling Techniques

> **NCT03813030** · NA · COMPLETED · sponsor: **Joanneum Research Forschungsgesellschaft mbH** · enrollment: 26 (actual)

## Conditions studied

- Healthy
- Dermal Pharmacokinetic Measurement

## Interventions

- **PROCEDURE:** Intravenous infusion of lidocaine
- **DRUG:** Lidocaine 2.5% and Prilocaine 2.5% cream", USP (2.5% lidocaine, 2.5% prilocaine, Actavis Pharma incorporated, USA)
- **DRUG:** Lidocorit 2%-Ampullen" (Gebro Pharma Gesellschaft mit beschränkter Haftung, Austria)
- **DEVICE:** Dermal open flow microperfusion
- **DEVICE:** Dermal Microdialysis
- **PROCEDURE:** Blood sampling in dermal sampling visit
- **PROCEDURE:** Blood sampling in clearance visit

## Key facts

- **NCT ID:** NCT03813030
- **Lead sponsor:** Joanneum Research Forschungsgesellschaft mbH
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2019-01-16
- **Primary completion:** 2019-08-28
- **Final completion:** 2019-08-28
- **Target enrollment:** 26 (ACTUAL)
- **Last updated:** 2023-02-10


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03813030

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03813030, "An Exploratory Study in Healthy Volunteers to Investigate the Cross-talk Between Local Drug Concentrations in the Skin and Systemic Concentrations During Topical Bioequivalence Studies Using Dermal Sampling Techniques". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT03813030. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*