Pevonedistat, Azacitidine, Fludarabine Phosphate, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

NCT03813147 · clinicaltrials.gov ↗

PHASE1

Phase

COMPLETED

Status

12

Enrollment

NIH

Sponsor class

Conditions

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
Recurrent Acute Myeloid Leukemia
Recurrent Myelodysplastic Syndrome
Refractory Acute Myeloid Leukemia
Refractory Myelodysplastic Syndrome

Interventions

DRUG: Azacitidine
DRUG: Cytarabine
DRUG: Fludarabine Phosphate
DRUG: Methotrexate
DRUG: Pevonedistat
DRUG: Therapeutic Hydrocortisone

Sponsor

National Cancer Institute (NCI)

Collaborators

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