# Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers

> **NCT03816332** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 12 (actual)

## Conditions studied

- Clinical Stage III Cutaneous Melanoma AJCC v8
- Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
- Clinical Stage IV Cutaneous Melanoma AJCC v8
- Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8
- Metastatic Basal Cell Carcinoma
- Metastatic Melanoma
- Metastatic Merkel Cell Carcinoma
- Metastatic Skin Squamous Cell Carcinoma
- Pathologic Stage III Cutaneous Melanoma AJCC v8
- Pathologic Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
- Pathologic Stage IIIA Cutaneous Melanoma AJCC v8
- Pathologic Stage IIIA Cutaneous Merkel Cell Carcinoma AJCC v8
- Pathologic Stage IIIB Cutaneous Melanoma AJCC v8
- Pathologic Stage IIIB Cutaneous Merkel Cell Carcinoma AJCC v8
- Pathologic Stage IIIC Cutaneous Melanoma AJCC v8
- Pathologic Stage IIID Cutaneous Melanoma AJCC v8
- Pathologic Stage IV Cutaneous Melanoma AJCC v8
- Pathologic Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8
- Unresectable Basal Cell Carcinoma
- Unresectable Melanoma
- Unresectable Merkel Cell Carcinoma

## Interventions

- **BIOLOGICAL:** Ipilimumab
- **BIOLOGICAL:** Nivolumab
- **DRUG:** Prednisone
- **DRUG:** Tacrolimus

## Key facts

- **NCT ID:** NCT03816332
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2019-11-08
- **Primary completion:** 2022-10-11
- **Final completion:** 2026-09-19
- **Target enrollment:** 12 (ACTUAL)
- **Last updated:** 2026-04-30


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03816332

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03816332, "Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT03816332. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*