# TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies

> **NCT03849651** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **St. Jude Children's Research Hospital** · enrollment: 69 (actual)

## Conditions studied

- Acute Lymphoblastic Leukemia (ALL)
- Acute Myeloid Leukemia (AML)
- Myelodysplastic Syndromes (MDS)
- NK-Cell Leukemia
- Hodgkin Lymphoma
- Non Hodgkin Lymphoma (NHL)
- Juvenile Myelomonocytic Leukemia (JMML)
- Chronic Myeloid Leukemia (CML)

## Interventions

- **DRUG:** Cyclophosphamide
- **BIOLOGICAL:** Fludarabine
- **DRUG:** Thiotepa
- **DRUG:** Melphalan
- **BIOLOGICAL:** G-csf
- **DRUG:** Mesna
- **DEVICE:** CliniMACS
- **BIOLOGICAL:** ATG (rabbit)
- **DRUG:** Blinatumomab
- **BIOLOGICAL:** TCRα/β+
- **BIOLOGICAL:** CD19+
- **BIOLOGICAL:** CD45RA-depleted DLI

## Key facts

- **NCT ID:** NCT03849651
- **Lead sponsor:** St. Jude Children's Research Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2019-01-31
- **Primary completion:** 2024-08-07
- **Final completion:** 2026-06-07
- **Target enrollment:** 69 (ACTUAL)
- **Last updated:** 2026-04-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03849651

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03849651, "TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies". Retrieved via AI Analytics 2026-07-20 from https://api.ai-analytics.org/clinical/NCT03849651. Licensed CC0.

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