# Dose Response Relationship of Oxytocin on Irritability in Youths

> **NCT03863288** · PHASE1,PHASE2 · TERMINATED · sponsor: **University of Nebraska** · enrollment: 60 (actual)

## Conditions studied

- Irritable Mood

## Interventions

- **PROCEDURE:** Functional MRI (fMRI)
- **DRUG:** Oxytocin Intranasal Spray 8 International Unit (8IU)
- **DRUG:** Oxytocin intranasal spray 24 International Unit (24IU)
- **DRUG:** Oxytocin intranasal spray 48 International Unit (48IU)
- **DRUG:** Oxytocin intranasal spray 80 International Unit (80IU)
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT03863288
- **Lead sponsor:** University of Nebraska
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2022-02-18
- **Primary completion:** 2024-02-27
- **Final completion:** 2024-02-27
- **Target enrollment:** 60 (ACTUAL)
- **Why stopped:** Per DSMB's recommendation
- **Last updated:** 2025-03-14

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03863288

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03863288, "Dose Response Relationship of Oxytocin on Irritability in Youths". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT03863288. Licensed CC0.

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