Safety, Efficacy, Immunogenicity Study of GSK Biologicals' HBV Viral Vector and Adjuvanted Proteins Vaccine (GSK3528869A) in Adult Patients With Chronic Hepatitis B Infection
Stopped Following the primary phase (24 weeks post last vaccination) the predefined efficacy endpoint was not met. Noting the lack of efficacy and with the objective to prioritize participants' safety GSK has decided on the early termination of the study.
Conditions
Interventions
- BIOLOGICAL: ChAd155-hIi-HBV low dose formulation
- BIOLOGICAL: ChAd155-hIi-HBV high dose formulation
- BIOLOGICAL: HBc-HBs/AS01B-4 low dose formulation
- BIOLOGICAL: HBc-HBs/AS01B-4 high dose formulation
- BIOLOGICAL: MVA-HBV low dose formulation
- BIOLOGICAL: MVA-HBV high dose formulation
- DRUG: Placebo
Sponsor
GlaxoSmithKline