# A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator, Olinciguat (IW-1701), in Healthy Volunteers

> **NCT03892499** · PHASE1 · COMPLETED · sponsor: **Cyclerion Therapeutics** · enrollment: 24 (actual)

## Conditions studied

- Healthy

## Interventions

- **DRUG:** Olinciguat
- **DRUG:** Itraconazole

## Key facts

- **NCT ID:** NCT03892499
- **Lead sponsor:** Cyclerion Therapeutics
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2019-05-03
- **Primary completion:** 2019-06-23
- **Final completion:** 2019-07-03
- **Target enrollment:** 24 (ACTUAL)
- **Last updated:** 2019-07-15


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03892499

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03892499, "A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator, Olinciguat (IW-1701), in Healthy Volunteers". Retrieved via AI Analytics 2026-06-05 from https://api.ai-analytics.org/clinical/NCT03892499. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*