# A Trial of CHOP-R Therapy, With or Without Acalabrutinib, in Patients With Newly Diagnosed Richter's Syndrome

> **NCT03899337** · PHASE2 · RECRUITING · sponsor: **University of Birmingham** · enrollment: 105 (estimated)

## Conditions studied

- Richter Syndrome

## Interventions

- **DRUG:** Acalabrutinib
- **DRUG:** Cyclophosphamide
- **DRUG:** Doxorubicin
- **DRUG:** Vincristine
- **DRUG:** Prednisolone
- **DRUG:** Rituximab

## Key facts

- **NCT ID:** NCT03899337
- **Lead sponsor:** University of Birmingham
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2019-07-23
- **Primary completion:** 2025-10-31
- **Final completion:** 2027-05-31
- **Target enrollment:** 105 (ESTIMATED)
- **Last updated:** 2023-01-09

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03899337

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03899337, "A Trial of CHOP-R Therapy, With or Without Acalabrutinib, in Patients With Newly Diagnosed Richter's Syndrome". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT03899337. Licensed CC0.

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