# A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia

> **NCT03914625** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 6720 (estimated)

## Conditions studied

- B Acute Lymphoblastic Leukemia
- B Lymphoblastic Lymphoma
- Down Syndrome

## Interventions

- **DRUG:** Asparaginase Erwinia chrysanthemi
- **BIOLOGICAL:** Blinatumomab
- **DRUG:** Cyclophosphamide
- **DRUG:** Cytarabine
- **DRUG:** Dexamethasone
- **DRUG:** Doxorubicin Hydrochloride
- **DRUG:** Leucovorin Calcium
- **DRUG:** Mercaptopurine
- **DRUG:** Mercaptopurine Oral Suspension
- **DRUG:** Methotrexate
- **DRUG:** Pegaspargase
- **DRUG:** Prednisolone
- **DRUG:** Prednisone
- **RADIATION:** Radiation Therapy
- **RADIATION:** Radiation Therapy
- **DRUG:** Thioguanine
- **DRUG:** Vincristine Sulfate

## Key facts

- **NCT ID:** NCT03914625
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2019-07-03
- **Primary completion:** 2027-09-30
- **Final completion:** 2027-09-30
- **Target enrollment:** 6720 (ESTIMATED)
- **Last updated:** 2026-05-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03914625

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03914625, "A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT03914625. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*