# DOSE Trial of Opioid Sparing Effect

> **NCT03938857** · PHASE1 · TERMINATED · sponsor: **Duke University** · enrollment: 30 (actual)

## Conditions studied

- Dexmedetomidine
- Mechanical Ventilation Complication
- Critically Ill

## Interventions

- **DRUG:** Fentanyl
- **DRUG:** Dexmedetomidine
- **DRUG:** Dexmedetomidine
- **DRUG:** Dexmedetomidine

## Key facts

- **NCT ID:** NCT03938857
- **Lead sponsor:** Duke University
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2019-07-18
- **Primary completion:** 2020-10-21
- **Final completion:** 2020-11-06
- **Target enrollment:** 30 (ACTUAL)
- **Why stopped:** Enrollment challenging during the pandemic COVID 19
- **Last updated:** 2021-11-05

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03938857

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03938857, "DOSE Trial of Opioid Sparing Effect". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT03938857. Licensed CC0.

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