# Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) Combined With Immune Checkpoint Inhibition After High-Dose External Beam Radiation Therapy in Treating Patients With Unresectable Liver Cancer

> **NCT03942328** · PHASE1,PHASE2 · RECRUITING · sponsor: **Mayo Clinic** · enrollment: 85 (estimated)

## Conditions studied

- Stage III Hepatocellular Carcinoma AJCC v8
- Stage III Intrahepatic Cholangiocarcinoma AJCC v8
- Stage IV Hepatocellular Carcinoma AJCC v8
- Stage IV Intrahepatic Cholangiocarcinoma AJCC v8
- Unresectable Hepatocellular Carcinoma
- Unresectable Intrahepatic Cholangiocarcinoma

## Interventions

- **BIOLOGICAL:** Atezolizumab
- **BIOLOGICAL:** Bevacizumab
- **RADIATION:** External Beam Radiation Therapy
- **PROCEDURE:** Pheresis
- **BIOLOGICAL:** Pneumococcal 13-valent Conjugate Vaccine
- **BIOLOGICAL:** Therapeutic Autologous Dendritic Cells
- **BIOLOGICAL:** Durvalumab
- **PROCEDURE:** Esophagogastroduodenoscopy
- **PROCEDURE:** Computed Tomography
- **PROCEDURE:** Positron Emission Tomography
- **PROCEDURE:** Magnetic Resonance Imaging
- **PROCEDURE:** Biopsy Procedure
- **PROCEDURE:** Biospecimen Collection

## Key facts

- **NCT ID:** NCT03942328
- **Lead sponsor:** Mayo Clinic
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2019-09-19
- **Primary completion:** 2029-08-31
- **Final completion:** 2029-08-31
- **Target enrollment:** 85 (ESTIMATED)
- **Last updated:** 2026-04-20

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03942328

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03942328, "Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) Combined With Immune Checkpoint Inhibition After High-Dose External Beam Radiation Therapy in Treating Patients With Unresectable Liver Cancer". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT03942328. Licensed CC0.

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