# Stroke Prevention With Hydroxyurea Enabled Through Research and Education (SPHERE)

> **NCT03948867** · PHASE2 · ENROLLING_BY_INVITATION · sponsor: **Children's Hospital Medical Center, Cincinnati** · enrollment: 202 (estimated)

## Conditions studied

- Sickle Cell Anemia in Children

## Interventions

- **DRUG:** Hydroxyurea
- **DIAGNOSTIC_TEST:** Elevated Arm TCD Examination
- **DIAGNOSTIC_TEST:** Normal Arm TCD Examination

## Key facts

- **NCT ID:** NCT03948867
- **Lead sponsor:** Children's Hospital Medical Center, Cincinnati
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ENROLLING_BY_INVITATION
- **Start date:** 2019-04-24
- **Primary completion:** 2026-12-31
- **Final completion:** 2026-12-31
- **Target enrollment:** 202 (ESTIMATED)
- **Last updated:** 2025-07-17

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03948867

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03948867, "Stroke Prevention With Hydroxyurea Enabled Through Research and Education (SPHERE)". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT03948867. Licensed CC0.

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