De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer

Conditions

• Basaloid Squamous Cell Carcinoma
• Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
• Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
• Oropharyngeal Squamous Cell Carcinoma
• Papillary Squamous Cell Carcinoma
• Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
• Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
• Squamous Cell Carcinoma

Interventions

• PROCEDURE: Biopsy Procedure
• PROCEDURE: Biospecimen Collection
• DRUG: Cisplatin
• PROCEDURE: Computed Tomography
• OTHER: Fludeoxyglucose F-18
• RADIATION: Image Guided Radiation Therapy
• RADIATION: Intensity-Modulated Radiation Therapy
• PROCEDURE: Magnetic Resonance Imaging
• BIOLOGICAL: Nivolumab
• PROCEDURE: Positron Emission Tomography
• OTHER: Quality-of-Life Assessment
• OTHER: Questionnaire Administration

Sponsor

National Cancer Institute (NCI)

Collaborators

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