# Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa...

> **NCT03952650** · PHASE1,PHASE2 · COMPLETED · sponsor: **National Institute of Allergy and Infectious Diseases (NIAID)** · enrollment: 252 (actual)

## Conditions studied

- Malaria

## Interventions

- **DRUG:** Chloroquine Phosphate
- **BIOLOGICAL:** PfSPZ Challenge
- **DRUG:** Pyrimethamine
- **DRUG:** Coartem
- **DRUG:** ibuprofen

## Key facts

- **NCT ID:** NCT03952650
- **Lead sponsor:** National Institute of Allergy and Infectious Diseases (NIAID)
- **Sponsor class:** NIH
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2019-05-23
- **Primary completion:** 2021-02-10
- **Final completion:** 2021-02-10
- **Target enrollment:** 252 (ACTUAL)
- **Last updated:** 2022-07-12


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03952650

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03952650, "Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa...". Retrieved via AI Analytics 2026-06-05 from https://api.ai-analytics.org/clinical/NCT03952650. Licensed CC0.

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